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Strengthen zoonotic disease preparedness through coordination and knowledge sharing

A coordinated international alliance of high-containment laboratories that optimizes collaboration and knowledge exchange to protect human health, animal health, and agricultural resources.

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Leverage capacity for diagnostics, research, and training.
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Strengthen international coordination to support science-based decision-making.
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Establish and sustain trusted partnerships.
Our history

About the Biosafety Level 4 Zoonotic Laboratory Network

High-containment biosafety level-4 (BSL-4) laboratories are unique facilities that make up a small percentage of laboratories worldwide. Although few in number, they perform high-impact studies on the world’s most deadly pathogens for which readily available vaccines or therapeutics are limited or lacking. Many are reference centres, providing scientific advice in addition to diagnostic support and tools to countries throughout the world, and exist as centres of excellence to support human and animal health.

Conducting research in high-containment laboratories requires many considerations, including specialized facilities and equipment, enhanced biosafety practices, and highly trained personnel. To help address these and other unique considerations, a network of collaborators is beneficial for identifying best practices for working in biosafety level 4 (BSL-4) facilities. The BSL4ZNet was envisioned as a network to provide support to this community, establish open lines of communication, and identify and address gaps across government agencies.

In 2016, the Canadian Food Inspection Agency (CFIA) hosted an inaugural meeting by bringing together representatives from various animal and public health government agencies to address the rising challenges and risks posed by zoonotic pathogens and the potential to move forward collectively to establish a functioning network. The meeting established a network of BSL-4 facilities charged with establishing avenues to share information, knowledge, materials, and expertise to push forward a concerted effort against future threats.

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Meet our

Member institutions

We are a network that fosters International collaboration through regular communication, learning events, and shared best practices.

Europe
Germany
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Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health
The Friedrich-Loeffler-Institut is Germany's leading research center for animal health, focusing on veterinary research and emerging infectious diseases. It conducts research on zoonotic
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Robert Koch Institute (RKI)
The Robert Koch Institute (RKI) is a public health institute in Germany. It plays a key role in detecting, preventing, and combating infectious diseases, also focusing on high-risk pathogens.
United Kingdom
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Animal and Plant Health Agency, Weybridge Veterinary Laboratories
The Animal and Plant Health Agency (APHA) works across Great Britain to protect animal and plant health to benefit people, the economy, and the environment. APHA is
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Defence Science and Technology Laboratory - Ministry of Defence of the United Kingdoms
The Defence Science and Technology Laboratory (Dstl) brings mission success to UK defence and security through science and technology advantage. Dstl focuses on defence research, including developing
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UK Health Security Agency (UKHSA), Porton Down Laboratory
The UK Health Security Agency (UKHSA) prepares for and responds to infectious diseases, and environmental hazards, to keep all our communities safe, save lives and protect livelihoods. We provide
North America
Canada
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Canadian Food Inspection Agency (CFIA), National Centre for Foreign Animal Disease (NCFAD)
The Canadian Food Inspection Agency (CFIA) is dedicated to safeguarding food, animals, and plants to protect the health and well-being of Canadians, the environment, and the economy. The CFIA enforces
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Public Health Agency of Canada (PHAC), National Microbiology Laboratory (NML)
The National Microbiology Laboratory (NML) is a key part of the Public Health Agency of Canada, conducting vital research on infectious diseases. It focuses on emerging pathogens and the development
United States
Centers for Disease Control and Prevention (CDC), Emerging Infectious Disease Laboratory
The CDC’s Emerging Infectious Disease Laboratory conducts research to identify and respond to newly emerging infectious diseases. It studies disease patterns, develops diagnostic tools, and helps
Oceania
Australia
Commonwealth Scientific and Industrial Research Organization (CSIRO), Australian Centre for Disease Preparedness (ACDP)
CSIRO is Australia's premier scientific research agency, conducting research across various sectors, including health, agriculture, and the environment. The Australian Centre for Disease Preparedness