High-containment biosafety level-4 (BSL-4) laboratories are unique facilities that make up a small percentage of laboratories worldwide. Although few in number, they perform high-impact studies on the world’s most deadly pathogens for which readily available vaccines or therapeutics are limited or lacking. Many are reference centres, providing scientific advice in addition to diagnostic support and tools to countries throughout the world, and exist as centres of excellence to support human and animal health.
Conducting research in high-containment laboratories requires many considerations, including specialized facilities and equipment, enhanced biosafety practices, and highly trained personnel. To help address these and other unique considerations, a network of collaborators is beneficial for identifying best practices for working in biosafety level 4 (BSL-4) facilities. The BSL4ZNet was envisioned as a network to provide support to this community, establish open lines of communication, and identify and address gaps across government agencies.
In 2016, the Canadian Food Inspection Agency (CFIA) hosted an inaugural meeting by bringing together representatives from various animal and public health government agencies to address the rising challenges and risks posed by zoonotic pathogens and the potential to move forward collectively to establish a functioning network. The meeting established a network of BSL-4 facilities charged with establishing avenues to share information, knowledge, materials, and expertise to push forward a concerted effort against future threats.